Simone supervises PhD students, has taught design studios at UG and PG levels, and contributed lectures for theory courses in architecture (Architectural Theory, ARCH10002) and landscape architecture (Situating Landscape Architectural Theory, ARCH11272). From 2018 to 2023, he was Course Organiser and Studio Leader for Architectural Design 3: Explorations (ARCH10001), also co-leading a studio in Architectural Design 4: Tectonics (ARCH10003). He also supervised Architecture Dissertation (ARJA10002) students and contributed to Academic Portfolio (ARCH10005). Since 2023, he is the Director of the Master of Architecture, and the Course Organiser for the Modular Studio Pathway (Architectural Design Studio C, ARCH1108; Architectural Design Studio D, ARCH11090; Architectural Design Studio B, ARCH11096; and Architectural Design Studio G, ARJA11003). He is also a Cohort Lead, and the Course Organiser for Design Report (ARCH11069) and Academic Portfolio 2 (ARJA11001). 

Simone’s research, articulated through writing, teaching, and architectural practice, investigates the technical infrastructures, theories, and methodological approaches required to move architectural discourse and practice beyond extraction, ecocide, and environmental injustice; and to challenge narrow disciplinary and economic understandings of authorship, habitation, use, and value. He is interested in the conceptualisation, production, and circulation of building materials, with a particular focus on reuse and repurposing. 

His monograph Ecologies of inception: Design Potentials on a Warming Planet (Routledge 2022) problematizes the still-prevailing modern paradigm of design practice: the technical tabula rasa, a tendency to begin from scratch and use raw, amorphous, and obedient materials. Instead, the philosophy of design developed in the text prompts—through a variety of case studies, thinkers, and disciplines—a collective reconsideration of value, dissociating it from the projects and signatures of any one author or generation. As an alternative, the book introduces a nodal and exaptive paradigm for design: a conceptual and methodological toolset for engaging the durational and anthropocenic materiality of the third millennium, and for radically prioritizing practices of maintenance, reuse, care, and co-option. This approach, which is inspired by (and builds upon) evolutionary biology, technological disobedience, queer use, adaptive reuse, experimental preservation, and improvisational practices such as collage, adhocism, bricolage, and kit-bashing, refuses to reduce pre-existing material substrates to abstract lists of properties or featureless lumps, encountering them on their own terms—as situated individuals and co-authors.

Simone is currently collaborating with radical architect Alessandro Poli on a book that will revisit and critically assess the project Zeno, a Self-Sufficient Culture, which Poli first developed between 1972 and 1980 in the context of the research on Extra-Urban Material Culture at the Faculty of Architecture in Florence, and which he first exhibited with Superstudio at the 1978 Venice Biennale.